Prostate cancer, mostly common among men over 50s, can be life threatening. Though it grows slower compared to other cancer, it can spread to other parts of the body, before you know it. Earlier we had discussed its symptoms, risk factors and early detection. (Understanding Prostate Cancer: Risk Factors, Symptoms, and Early Detection). We had also discussed the role of family history and genetics in raising the risk. Today, let’s know how?
Yes, prostate cancer, no doubt, can be life threatening. Though lifestyle and environmental factors are responsible for the cancer to occur, family history and genetics can also significantly increase the risk of prostate cancer.
Family History
If a person’s closest relative (first degree relative) like father, brother or son, has been diagnosed with prostate cancer, then the risk of developing prostate cancer doubles for the person. If two or more relatives of the person are affected, or if they were diagnosed at a younger age, the risk further increases, suggesting a strong inherited component to prostate cancer.
Not just this, it has also been witnessed that a family history of breast or ovarian cancer, especially related to mutations in BRCA1 or BRCA2 genes, can also significantly increase the risk of prostate cancer. Though BRCA1 & BRCA2 genes are known for their links to cancer in women, it can significantly increase the risk of prostate cancer in men, when mutated
Role of Genetics
Not just BRCA1 or BRCA2, other inherited gene changes like HOXB13, ATM, CHEK2, and Lynch syndrome-related genes can make men more prone to developing prostate cancer. Though, not all prostate cancer related to genetics are aggressive, you should still get checked and tested. Genetic testing and counselling can help assess your personal risk and guide early screening decisions.
What to do?
- KNOW YOUR FAMILY HISTORY: Talk to your parents, your grandparents, your nearest relatives, know and keep a record of any cancers in the family.
- MEET THE DOCTOR: With having a strong family history of cancers, it is mandatory to discuss this with your doctor and go for early and frequent tests/screenings on your doctor’s advice.
- CONSIDER GENETIC COUNSELLING: If you have a multiple family history of prostate, breast or ovarian cancers.
Knowing, understanding your family history and genetic background can maximize your chances of detecting prostate cancer at an early stage, Or especially in keeping your prostate healthy. Though you can’t change your genes, early detection and awareness can make a significant difference in outcomes.